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The research, published Nov. 13 by the Journal of Clinical Investigation, provides new clues in to the workings of a protein referred to as apolipoprotein E4, or ApoE4. Individuals who carry two copies of the gene have roughly eight to 10 times the risk of getting Alzheimer’s disease than individuals who do not. The brand new results mark a stage toward resolving a longstanding issue that scientists have had about exactly how ApoE4 increases someone’s risk for the disease. The findings indicate differences in the way that amyloid-beta is taken off the brain based on which ApoE proteins is involved. Scientists found that when ApoE4 exists, the mind is less effective at ridding itself of the toxic materials, because a molecule that is much slower at eliminating the substance becomes a lot more involved.